Turkey and the European Sclerosis
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ALTA assists in finding the proper strategy, building European Consortia and putting science in the most appropriate administrative and management framework.
Turkey – Multiple Sclerosis (MS) Association of Turkey
New approach needed to tackle parasitic liver disease in Europe and Turkey. The study assessed the prevalence of the disease among rural populations in the three countries. Prevalence of abdominal cystic echinococcosis in rural Bulgaria, Romania and Turkey. The absence of CE from top-level peer review journals contributes to its neglect status. For further information, visit iCARE-2 website. Our company is in the process of planning, development and implementation of a quality management system in accordance with the standard UNI EN ISO Home Reserved Pictures. Past projects. A single T cell epitope drives the neutralizing anti-drug antibody response to natalizumab in multiple sclerosis patients.
However, it remains important to undertake regular monitoring in patients receiving such drugs. Fingolimod was the first oral MS drug to be approved, although teriflunomide and DMF are also now available. The practicing neurologist must have enough knowledge of the specific qualities of each oral compound to enable them to follow and monitor their patients properly.
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This includes detailed knowledge of the safety profiles of each agent, so that patients can be informed of the potential adverse events, expected workup at initiation and ongoing regular monitoring that will be necessary. For individuals in whom fingolimod therapy is planned, the initial work up may cover ophthalmologic, cardiac, haematologic and biochemistry studies, together with dermatologic examinations especially for patients with naevi. Before initiating fingolimod therapy, the patient should be tested for anti-varicella zoster virus VZV antibodies.
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If the immunoglobulin Ig G test is negative, the patient should be vaccinated, preferably with a strategy where two injections are given, one month apart; fingolimod treatment should be initiated 1 month after the second vaccination. Electrocardiography, heart rate and blood pressure monitoring is required before the first dose of fingolimod, and continuously for the first 6 h after treatment.
However, patients who develop clinically significant heart-rhythm or other cardiac problems should remain in hospital overnight, with monitoring continuing until symptoms resolve. In such patients the second dose of fingolimod should be withheld and alternative agents may be favoured therafter.
Although some patients switch to an every-other-day fingolimod regimen, this practice has no evidence base. Fingolimod 0.
The lower values do not correlate with infection rate, and within 45 days of fingolimod discontinuation, the mean lymphocyte count returns to the normal range. Almost a dozen cases of progressive multifocal leucoencephalopathy PML have been reported in patients with MS who switched to fingolimod after natalizumab therapy.
These cases were all shown to have developed PML —as detected retrospectively by earlier magnetic resonance imaging scans — either before starting fingolimod or soon after, and therefore were considered not to be related directly to the oral agent. However, one person with neuromyelitis optica spectrum disorder NMOSD and two people with MS who never received prior immunosuppressive or natalizumab treatment developed PML after taking fingolimod. This indicates that people who are anti-JC virus antibody aJCV-Ab -positive, and who receive fingolimod in the absence of other risk factors for PML, are not immune to developing this unwanted complication.
This raises the importance of regular monitoring in patients receiving fingolimod, despite the extremely low risk of them developing PML. Live-attenuated vaccines such as rubella, polio, yellow fever, mumps, measles or smallpox are contraindicated during fingolimod therapy, as well as during most second- and third-line MS therapies, especially the monoclonal antibodies.
Teriflunomide has a less-extensive workup protocol than fingolimod, but the monitoring of hepatic, haematologic, renal and other metabolic parameters should not be neglected. Patients are not advised to commence teriflunomide therapy if ALT elevations more than two times the ULN were observed twice within 6 months prior to treatment initiation.
In patients receiving teriflunomide, liver enzyme levels should be monitored regularly through LETs. If an increase between 2- and 3-fold the ULN is detected, monitoring must be performed weekly. Therapy should be discontinued if an elevation greater than 3-fold the ULN is confirmed. Although lymphopenia may be seen with teriflunomide use, generally the decrease remains limited. However, recent data on pregnancy outcomes following maternal and paternal exposure to teriflunomide do not indicate teratogenic signals in MS patients treated with this agent.
Nevertheless, once pregnancy or any fertility related treatments are considered or the drug is stopped for safety or other concerns , it is important for the patient to undergo a washout procedure with either cholestyramine or activated charcoal. Washout with cholestyramine 8 mg tid eliminates teriflunomide i. No cases of PML have been reported with teriflunomide use. However, three cases of PML have been reported with leflunomide. Two patients developed PML while receiving leflunomide treatment for rheumathoid arthritis; the other patient was being treated for SLE; all were on many other concomitant treatments and currently there is no evidence that links the use of leflunomide or teriflunomide with PML development.
The DMF regimen commences with a starting dose of mg bid for the first week, increasing to the optimal dose of mg bid 1 week later. Such symptoms may occur in up to one-third of patients but generally are not severe and disappear within the first few weeks of treatment. Flushing can be managed with aspirin mg bid and antihistamines standard regimens. The GI side-effects may be treated with dietary strategies, according to the specific symptoms affecting the individual.
Prevalence of Multiple Sclerosis in a Turkish City Bordering an Iron and Steel Factory
These could involve taking DMF after meals, with fat-containing foods, or introducing probiotics. Alternatively, some patients require treatment with agents such as proton pump blockers or H2-receptor antagonists, antiemetics e.
The second case, which was not fatal, also had prolonged severe lymphopenia grade III , which is on the drug's label as a risk factor for PML. Whatever the possible explanation might be for PML development in patients receiving newer long-term MS treatments, it is important to monitor their physiological parameters more frequently than is necessary for first-line MS therapies. Other than LET, CBC with complete lymphocyte counts should be repeated regularly, and more frequently depending on any changes observed. The monoclonal antibody natalizumab can only be administered to patients with MS by certified centres.
In these severe cases, natalizumab should be stopped: anaphylaxis may be expected if repeated. In addition, such reactions may correlate with the development of neutralizing autoantibodies and therefore the patient would become a non-responder. It has been suggested that HLA-DRB1 genotyping before treatment may help to identify those patients with MS who are at heightened risk of developing the serious systemic hypersensitivity reactions associated with natalizumab administration, but the practicality of this is questionable.
In addition to biochemistry and haematology studies, aJCV-Ab status is needed when considering natalizumab use, and when planning further risk management strategies for progressive PML in patients found to be aJCV-Ab-positive. Once patients begin natalizumab they should be monitored closely. If aJCV-Ab status is negative we perform MRI annually for the first 2 years and every 6 months thereafter unless any clinical change is observed in the meantime.
Cognitive testing is repeated annually, unless cognitive and personality changes are reported in the meantime. Close monitoring for the development of any new neurologic symptom s as well as any unusual MRI findings in a patient at heightened risk should alert the physician of the potential for PML development. The use of high dose intravenous methylprednisolone is controversial.
Recent case reports that indicate improvements in some patients with PML who received the antiretroviral agent maraviroc mg b. However, these were observational case reports and currently this therapy has no evidence basis.
Alemtuzumab is a humanized monoclonal antibody to CD52 approved for the treatment of MS. As alemtuzumab can cause an immediate infusion reaction, the current practice is to administer mg IVMP on the first 3 days of each treatment course, with antihistamines. Oral prophylaxis for herpes simplex virus infection acyclovir mg twice daily for 1—2 months following each alemtuzumab treatment cycle should be given.
As any of these conditions may occur years after the last dose of alemtuzumab, extended follow-up for safety issues should continue at least until 48 months after the last infusion.http://argo-karaganda.kz/scripts/cirariwi/3212.php
Incidence and prevalence of multiple sclerosis in Europe: a systematic review
Monthly CBC with differential, biochemistry-serum creatinine levels , 3-monthly thyroid function tests TSH and autoantibodies and urinanalysis with microscopy need to be checked regularly for the first 4 years and whenever there is a suspicion thereafter. It has been shown that B lymphocytes are involved in the pathophysiology of MS, and the monoclonal antibody rituximab directed against the CD20 antigen acts as a B-cell-targeted therapy in the treatment of relapsing-remitting MS. Rituximab is not approved for MS treatment, but recently its use has increased in some centres for patients with treatment-resistant MS who have not suited other regimens.
There are different treatment protocols for rituximab. The most common one is to give twice mg intravenous infusions of rituximab on days 1 and 15, repeated every 6—9 months. Infusion reactions may occur during its administration.